Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis.

Polycyclic polyether natural products have fascinated chemists and biologists alike owing to their useful biological activity, highly complex structure and intriguing biosynthetic mechanisms. Following the original proposal for the polyepoxide origin of lasalocid and isolasalocid and the experimenta...

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Bibliographic Details
Main Authors: Hotta, K, Chen, X, Paton, R, Minami, A, Li, H, Swaminathan, K, Mathews, I, Watanabe, K, Oikawa, H, Houk, K, Kim, C
Format: Journal article
Language:English
Published: 2012