Increased IgG4 responses to multiple food and animal antigens indicate a polyclonal expansion and differentiation of pre-existing B cells in IgG4-related disease

<strong>Background:</strong> IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory condition, characterised by an elevated serum IgG4 concentration and abundant IgG4-positive plasma cells in the involved organs. An important question is whether the elevated IgG4 response is caus...

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Bibliographic Details
Main Authors: Culver, E, Vermeulen, E, Makuch, M, van Leeuwen, A, Sadler, R, Cargill, T, Klenerman, P, Aalberse, R, van Ham, S, Barnes, E, Rispens, T
Format: Journal article
Language:English
Published: BMJ Publishing Group 2015