Dissecting the contribution of dipeptide repeats to the toxicity in C9orf72 iPSC-derived neurons from ALS/FTD patients
<p>A large (GGGGCC) repeat expansion in C9ORF72 gene is the commonest genetic cause of amyotrophic lateral sclerosis (ALS). It causes both loss- and gain-of-function, but the relative contribution of the different mechanisms to the development of ALS remains uncertain. One of the pathomechanis...
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| Format: | Thesis |
| Language: | English |
| Published: |
2021
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