Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood-brain barrier: Therapeutic avenues

Mounting evidence has linked the metabolic disease to neurovascular disorders and cognitive decline. Using a murine model of a high-fat high-sugar diet mimicking obesity-induced type 2 diabetes mellitus (T2DM) in humans, we show that pro-inflammatory mediators and altered immune responses damage the...

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Bibliographic Details
Main Authors: Sheikh, MH, Errede, M, d'Amati, A, Khan, NQ, Fanti, S, Loiola, RA, McArthur, S, Purvis, GSD, O'Riordan, CE, Ferorelli, D, Dell'Erba, A, Kieswich, J, Reutelingsperger, C, Maiorano, E, Yaqoob, M, Thiemermann, C, Baragetti, A, Catapano, AL, Norata, GD, Marelli-Berg, F, Virgintino, D, Solito, E
Format: Journal article
Language:English
Published: Federation of American Societies for Experimental Biology 2021