Heat shock protein amplification improves cerebellar myelination in the Npc1nih mouse model

<p><strong>Background</strong><br> Niemann-Pick disease type C (NPC) is a rare prematurely fatal lysosomal lipid storage disease with limited therapeutic options. The prominent neuropathological hallmarks include hypomyelination and cerebellar atrophy. We previously demonstra...

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Bibliographic Details
Main Authors: Gray, J, Fernández-Suárez, ME, Falah, M, Smith, D, Smith, C, Kaya, E, Palmer, AM, Fog, CK, Kirkegaard, T, Platt, FM
Format: Journal article
Language:English
Published: Elsevier 2022