Assessment of the reproducibility and inter-site transferability of the murine direct splenocyte mycobacterial growth inhibition assay (MGIA)

Tuberculosis (TB) vaccine candidates must be tested for safety and efficacy using preclinical challenge models prior to advancement to human trials, because of the lack of a validated immune correlate or biomarker of protection. New, unbiased tools are urgently needed to expedite the selection of va...

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Bibliografische gegevens
Hoofdauteurs: Tanner, R, Zelmer, A, Painter, H, Stylianou, E, Pinpathomrat, N, Harrington-Kandt, R, Biffar, L, Brennan, MJ, McShane, H, Fletcher, HA
Formaat: Internet publication
Taal:English
Gepubliceerd in: Cold Spring Harbor Laboratory 2021