Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase.

Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase.

Deacetoxycephalosporin C synthase from Streptomyces clavuligerus catalyses the conversion of the five-membered penicillin ring to the unsaturated six-membered cephem ring of deacetoxycephalosporin C. The effects on enzyme activity of the penicillin substrate sidechain and various cofactors were inve...

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Autors principals:	Dubus, A, Lloyd, MD, Lee, H, Schofield, C, Baldwin, J, Frere, J
Format:	Journal article
Idioma:	English
Publicat:	2001

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