Probing the penicillin sidechain selectivity of recombinant deacetoxycephalosporin C synthase.
Deacetoxycephalosporin C synthase from Streptomyces clavuligerus catalyses the conversion of the five-membered penicillin ring to the unsaturated six-membered cephem ring of deacetoxycephalosporin C. The effects on enzyme activity of the penicillin substrate sidechain and various cofactors were inve...
Hlavní autoři: | Dubus, A, Lloyd, MD, Lee, H, Schofield, C, Baldwin, J, Frere, J |
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Médium: | Journal article |
Jazyk: | English |
Vydáno: |
2001
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