HIV-1 promotes the degradation of components of the Type 1 IFN JAK/STAT 1 pathway and blocks antiviral ISG induction
Anti-retroviral therapy successfully suppresses HIV-1 infection, but fails to provide a cure. During infection Type 1 IFNs normally play an essential role in viral clearance, but in vivo IFN-a only has a modest impact on HIV-1 infection, suggesting its possible targeting by HIV. Here, we report that...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Published: |
Elsevier
2018
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