Penicillin derivatives inhibit the SARS-CoV-2 main protease by reaction with its nucleophilic cysteine

<p>The SARS-CoV-2 main protease (M<sup>pro</sup>) is a medicinal chemistry target for COVID-19 treatment. Given the clinical efficacy of β-lactams as inhibitors of bacterial nucleophilic enzymes, they are of interest as inhibitors of viral nucleophilic serine and cysteine...

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التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Malla, TR, Brewitz, L, Muntean, D-G, Aslam, H, Owen, CD, Salah, E, Tumber, A, Lukacik, P, Strain-Damerell, C, Mikolajek, H, Walsh, MA, Schofield, CJ
التنسيق:	Journal article
اللغة:	English
منشور في:	American Chemical Society 2022

Penicillin derivatives inhibit the SARS-CoV-2 main protease by reaction with its nucleophilic cysteine

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