Toward a quantitative understanding of the Wnt/beta-catenin pathway through simulation and experiment
Wnt signaling regulates cell survival, proliferation, and differentiation throughout development and is aberrantly regulated in cancer. The pathway is activated when Wnt ligands bind to specific receptors on the cell surface, resulting in the stabilization and nuclear accumulation of the transcripti...
| Main Authors: | , , , |
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| Format: | Journal article |
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Wiley
2013
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| _version_ | 1797084266739269632 |
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| author | Lloyd-Lewis, B Fletcher, A Dale, T Byrne, H |
| author_facet | Lloyd-Lewis, B Fletcher, A Dale, T Byrne, H |
| author_sort | Lloyd-Lewis, B |
| collection | OXFORD |
| description | Wnt signaling regulates cell survival, proliferation, and differentiation throughout development and is aberrantly regulated in cancer. The pathway is activated when Wnt ligands bind to specific receptors on the cell surface, resulting in the stabilization and nuclear accumulation of the transcriptional co‐activator β‐catenin. Mathematical and computational models have been used to study the spatial and temporal regulation of the Wnt/β‐catenin pathway and to investigate the functional impact of mutations in key components. Such models range in complexity, from time‐dependent, ordinary differential equations that describe the biochemical interactions between key pathway components within a single cell, to complex, multiscale models that incorporate the role of the Wnt/β‐catenin pathway target genes in tissue homeostasis and carcinogenesis. This review aims to summarize recent progress in mathematical modeling of the Wnt pathway and to highlight new biological results that could form the basis for future theoretical investigations designed to increase the utility of theoretical models of Wnt signaling in the biomedical arena. |
| first_indexed | 2024-03-07T01:53:03Z |
| format | Journal article |
| id | oxford-uuid:9ac7cf88-ef10-4d9a-8a2f-dbe0e4d4b1e5 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T01:53:03Z |
| publishDate | 2013 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:9ac7cf88-ef10-4d9a-8a2f-dbe0e4d4b1e52022-03-27T00:23:42ZToward a quantitative understanding of the Wnt/beta-catenin pathway through simulation and experimentJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9ac7cf88-ef10-4d9a-8a2f-dbe0e4d4b1e5Mathematical Institute - ePrintsWiley2013Lloyd-Lewis, BFletcher, ADale, TByrne, HWnt signaling regulates cell survival, proliferation, and differentiation throughout development and is aberrantly regulated in cancer. The pathway is activated when Wnt ligands bind to specific receptors on the cell surface, resulting in the stabilization and nuclear accumulation of the transcriptional co‐activator β‐catenin. Mathematical and computational models have been used to study the spatial and temporal regulation of the Wnt/β‐catenin pathway and to investigate the functional impact of mutations in key components. Such models range in complexity, from time‐dependent, ordinary differential equations that describe the biochemical interactions between key pathway components within a single cell, to complex, multiscale models that incorporate the role of the Wnt/β‐catenin pathway target genes in tissue homeostasis and carcinogenesis. This review aims to summarize recent progress in mathematical modeling of the Wnt pathway and to highlight new biological results that could form the basis for future theoretical investigations designed to increase the utility of theoretical models of Wnt signaling in the biomedical arena. |
| spellingShingle | Lloyd-Lewis, B Fletcher, A Dale, T Byrne, H Toward a quantitative understanding of the Wnt/beta-catenin pathway through simulation and experiment |
| title | Toward a quantitative understanding of the Wnt/beta-catenin pathway through simulation and experiment |
| title_full | Toward a quantitative understanding of the Wnt/beta-catenin pathway through simulation and experiment |
| title_fullStr | Toward a quantitative understanding of the Wnt/beta-catenin pathway through simulation and experiment |
| title_full_unstemmed | Toward a quantitative understanding of the Wnt/beta-catenin pathway through simulation and experiment |
| title_short | Toward a quantitative understanding of the Wnt/beta-catenin pathway through simulation and experiment |
| title_sort | toward a quantitative understanding of the wnt beta catenin pathway through simulation and experiment |
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