Targeting the hypoxia-inducible factor (HIF) pathway in cancer.
The central component of hypoxia sensing in the cell is the hypoxia-inducible factor (HIF) transcriptional complex. HIF activity is deregulated in many human cancers, especially those that are highly hypoxic. Hypoxic tumour cells are usually resistant to radiotherapy and most conventional chemothera...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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