High-resolution crystal structure of arthropod Eiger TNF suggests a mode of receptor engagement and altered surface charge within endosomes
<p>The tumour necrosis factor alpha (TNFα) superfamily of proteins are critical in numerous biological processes, such as in development and immunity. Eiger is the sole TNFα member described in arthropods such as in the important model organism <em>Drosophila</em>. To date there ar...
Main Authors: | Bertinelli, M, Paesen, G, Grimes, J, Renner, M |
---|---|
Format: | Journal article |
Language: | English |
Published: |
Nature Research
2019
|
Similar Items
-
A Drosophila model targets Eiger/TNFα to alleviate obesity-related insulin resistance and macrophage infiltration
by: Zhasmine Mirzoyan, et al.
Published: (2023-11-01) -
Altered endosomal-lysosomal biogenesis in melanoma
by: Giang T. Lam, et al.
Published: (2023-09-01) -
Crisis Responsibility Impact on Customer Loyalty Eiger through Post-Crisis Reputation
by: Sinjaya Kusuma, et al.
Published: (2021-12-01) -
Kilohertz Macromolecular Crystallography Using an EIGER Detector at Low X-ray Fluxes
by: Krishna P. Khakurel, et al.
Published: (2020-12-01) -
Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein
by: Renner, M, et al.
Published: (2016)