MeCP2 binding to DNA depends upon hydration at methyl-CpG.

MeCP2 is an essential transcriptional repressor that mediates gene silencing through binding to methylated DNA. Binding specificity has been thought to depend on hydrophobic interactions between cytosine methyl groups and a hydrophobic patch within the methyl-CpG-binding domain (MBD). X-ray analysis...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Ho, K, McNae, I, Schmiedeberg, L, Klose, R, Bird, A, Walkinshaw, MD
स्वरूप: Journal article
भाषा:English
प्रकाशित: 2008