MeCP2 binding to DNA depends upon hydration at methyl-CpG.
MeCP2 is an essential transcriptional repressor that mediates gene silencing through binding to methylated DNA. Binding specificity has been thought to depend on hydrophobic interactions between cytosine methyl groups and a hydrophobic patch within the methyl-CpG-binding domain (MBD). X-ray analysis...
主要な著者: | , , , , , |
---|---|
フォーマット: | Journal article |
言語: | English |
出版事項: |
2008
|