MeCP2 binding to DNA depends upon hydration at methyl-CpG.

MeCP2 is an essential transcriptional repressor that mediates gene silencing through binding to methylated DNA. Binding specificity has been thought to depend on hydrophobic interactions between cytosine methyl groups and a hydrophobic patch within the methyl-CpG-binding domain (MBD). X-ray analysis...

詳細記述

書誌詳細
主要な著者: Ho, K, McNae, I, Schmiedeberg, L, Klose, R, Bird, A, Walkinshaw, MD
フォーマット: Journal article
言語:English
出版事項: 2008