Chelation-controlled intermolecular hydroacylation: direct addition of alkyl aldehydes to functionalized alkenes.
The pendant methylsulfanyl group of aldehyde 1 provides chelation stabilization (see 3), thus allowing direct hydroacylation of functionalized electron-poor alkenes 2 in good yields under mild conditions. Electron-deficient alkynes can also be used as substrates. R = ester, arnide, imide, sulfone; d...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2004
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