Chelation-controlled intermolecular hydroacylation: direct addition of alkyl aldehydes to functionalized alkenes.
The pendant methylsulfanyl group of aldehyde 1 provides chelation stabilization (see 3), thus allowing direct hydroacylation of functionalized electron-poor alkenes 2 in good yields under mild conditions. Electron-deficient alkynes can also be used as substrates. R = ester, arnide, imide, sulfone; d...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2004
|
| _version_ | 1797084504694718464 |
|---|---|
| author | Willis, M McNally, S Beswick, P |
| author_facet | Willis, M McNally, S Beswick, P |
| author_sort | Willis, M |
| collection | OXFORD |
| description | The pendant methylsulfanyl group of aldehyde 1 provides chelation stabilization (see 3), thus allowing direct hydroacylation of functionalized electron-poor alkenes 2 in good yields under mild conditions. Electron-deficient alkynes can also be used as substrates. R = ester, arnide, imide, sulfone; dppe = 1,2-bis(diphenylphosphanyl)ethane. |
| first_indexed | 2024-03-07T01:56:02Z |
| format | Journal article |
| id | oxford-uuid:9bbf6f46-5745-4b89-a1df-b016ba4243cc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T01:56:02Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:9bbf6f46-5745-4b89-a1df-b016ba4243cc2022-03-27T00:30:57ZChelation-controlled intermolecular hydroacylation: direct addition of alkyl aldehydes to functionalized alkenes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9bbf6f46-5745-4b89-a1df-b016ba4243ccEnglishSymplectic Elements at Oxford2004Willis, MMcNally, SBeswick, PThe pendant methylsulfanyl group of aldehyde 1 provides chelation stabilization (see 3), thus allowing direct hydroacylation of functionalized electron-poor alkenes 2 in good yields under mild conditions. Electron-deficient alkynes can also be used as substrates. R = ester, arnide, imide, sulfone; dppe = 1,2-bis(diphenylphosphanyl)ethane. |
| spellingShingle | Willis, M McNally, S Beswick, P Chelation-controlled intermolecular hydroacylation: direct addition of alkyl aldehydes to functionalized alkenes. |
| title | Chelation-controlled intermolecular hydroacylation: direct addition of alkyl aldehydes to functionalized alkenes. |
| title_full | Chelation-controlled intermolecular hydroacylation: direct addition of alkyl aldehydes to functionalized alkenes. |
| title_fullStr | Chelation-controlled intermolecular hydroacylation: direct addition of alkyl aldehydes to functionalized alkenes. |
| title_full_unstemmed | Chelation-controlled intermolecular hydroacylation: direct addition of alkyl aldehydes to functionalized alkenes. |
| title_short | Chelation-controlled intermolecular hydroacylation: direct addition of alkyl aldehydes to functionalized alkenes. |
| title_sort | chelation controlled intermolecular hydroacylation direct addition of alkyl aldehydes to functionalized alkenes |
| work_keys_str_mv | AT willism chelationcontrolledintermolecularhydroacylationdirectadditionofalkylaldehydestofunctionalizedalkenes AT mcnallys chelationcontrolledintermolecularhydroacylationdirectadditionofalkylaldehydestofunctionalizedalkenes AT beswickp chelationcontrolledintermolecularhydroacylationdirectadditionofalkylaldehydestofunctionalizedalkenes |