Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure.

In HIV-infected persons, certain HLA class I alleles are associated with effective control of viremia, while others are associated with rapid disease progression. Among the most divergent clinical outcomes are the relatively good prognosis in HLA-B*5801 expressing persons and poor prognosis with HLA...

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Main Authors:	Ngumbela, K, Day, C, Mncube, Z, Nair, K, Ramduth, D, Thobakgale, C, Moodley, E, Reddy, S, de Pierres, C, Mkhwanazi, N, Bishop, K, van der Stok, M, Ismail, N, Honeyborne, I, Crawford, H, Kavanagh, D, Rousseau, C, Nickle, D, Mullins, J, Heckerman, D, Korber, B, Coovadia, H, Kiepiela, P, Goulder, P, Walker, B
Format:	Journal article
Language:	English
Published:	2008

Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure.

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