The sinus venosus progenitors separate and diversify from the first and second heart fields early in development.

AIMS: During development, the heart tube grows by differentiation of Isl1(+)/Nkx2-5(+) progenitors to the arterial and venous pole and dorsal mesocardium. However, after the establishment of the heart tube, Tbx18(+) progenitors were proposed to form the Tbx18(+)/Nkx2-5(-) sinus venosus and proepica...

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Bibliographic Details
Main Authors: Mommersteeg, M, Domínguez, J, Wiese, C, Norden, J, de Gier-de Vries, C, Burch, J, Kispert, A, Brown, N, Moorman, A, Christoffels, V
Format: Journal article
Language:English
Published: 2010