MicroRNA controlled adenovirus mediates anti-cancer efficacy without affecting endogenous microRNA activity.
MicroRNAs are small non-coding RNA molecules that regulate mRNA translation and stability by binding to complementary sequences usually within the 3' un-translated region (UTR). We have previously shown that the hepatic toxicity caused by wild-type Adenovirus 5 (Ad5WT) in mice can be prevented...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Public Library of Science
2011
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