Nur77 controls tolerance induction, terminal differentiation, and effector functions in NKT cells

Natural killer T (NKT) cells are self-reactive lymphocytes, yet how this lineage attains self-tolerance remains unknown. NKT cells constitutively express high levels of Nr4a1-encoded Nur77, a transcription factor that integrates signal strength downstream of the T cell receptor (TCR) within activate...

Полное описание

Библиографические подробности
Главные авторы: Kumar, A, Hill, TM, Gordy, LE, Suryadevara, N, Wu, L, Flyak, AI, Bezbradica, JS, Van Kaer, L, Joyce, S
Формат: Conference item
Язык:English
Опубликовано: American Association of Immunologists 2020