Cross-reactivity of hepatitis C virus specific vaccine-induced T cells at immunodominant epitopes.

Viral diversity is a challenge to the development of a hepatitis C virus (HCV) vaccine. Following vaccination of humans with adenoviral vectors, we determined the capacity of T cells to target common viral variants at immundominant epitopes ex vivo. We identified two major variants for epitopes NS3(...

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Bibliographic Details
Main Authors: Kelly, C, Swadling, L, Brown, A, Capone, S, Folgori, A, Salio, M, Klenerman, P, Barnes, E
Format: Journal article
Language:English
Published: Wiley 2015