Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality.

HIV-1 specific HLA-B-restricted CD8+ T cell responses differ from HLA-C-restricted responses in antiviral effectiveness. To investigate possible reasons for these differences, we characterized the frequency and polyfunctionality of immmunodominant HLA-B*57/B5801- and HLA-Cw*07-restricted CD8+ T cell...

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Bibliographic Details
Main Authors: Mkhwanazi, N, Thobakgale, C, van der Stok, M, Reddy, S, Mncube, Z, Chonco, F, Walker, B, Altfeld, M, Goulder, P, Ndung'u, T
Format: Journal article
Language:English
Published: 2010