Integrated proteomics unveils nuclear PDE3A2 as a regulator of cardiac myocyte hypertrophy

Integrated proteomics unveils nuclear PDE3A2 as a regulator of cardiac myocyte hypertrophy

<p><strong>Background:&nbsp;</strong>Signaling by cAMP is organized in multiple distinct subcellular nanodomains regulated by cAMP-hydrolyzing PDEs (phosphodiesterases). Cardiac &beta;-adrenergic signaling has served as the prototypical system to elucidate cAMP compartmenta...

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Bibliographic Details
Main Authors: Subramaniam, G, Schleicher, K, Kovanich, D, Zerio, A, Folkmanaite, M, Chao, Y-C, Surdo, NC, Koschinski, A, Hu, J, Scholten, A, Heck, AJR, Ercu, M, Sholokh, A, Park, KC, Klussmann, E, Meraviglia, V, Bellin, M, Zanivan, S, Hester, S, Mohammed, S, Zaccolo, M
Format: Journal article
Language:English
Published: American Heart Association 2023

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