Transcriptional profiling and immunophenotyping show sustained activation of blood monocytes in subpatent Plasmodium falciparum infection

Transcriptional profiling and immunophenotyping show sustained activation of blood monocytes in subpatent Plasmodium falciparum infection

Objectives Malaria, caused by Plasmodium infection, remains a major global health problem. Monocytes are integral to the immune response, yet their transcriptional and functional responses in primary Plasmodium falciparum infection and in clinical malaria are poorly understood. Methods The transcri...

Full description

Bibliographic Details
Main Authors:	Loughland, JR, Woodberry, T, Field, M, Andrew, DW, SheelaNair, A, Dooley, NL, Piera, KA, Amante, FH, Kenangalem, E, Price, RN, Engwerda, CR, Anstey, NM, McCarthy, JS, Boyle, MJ, Minigo, G
Format:	Journal article
Language:	English
Published:	Nature Publishing Group 2020

Similar Items

Plasmodium falciparum activates CD16+ dendritic cells to produce TNF and IL-10 in subpatent malaria
by: Loughland, JR, et al.
Published: (2018)

Characterization of blood dendritic and regulatory T cells in asymptomatic adults with sub-microscopic Plasmodium falciparum or Plasmodium vivax infection.
by: Kho, S, et al.
Published: (2016)

Parasite-dependent expansion of TNF receptor II-positive regulatory T cells with enhanced suppressive activity in adults with severe malaria.
by: Minigo, G, et al.
Published: (2009)

Assessment of subpatent Plasmodium infection in northwestern Ethiopia
by: Ashenafi Assefa, et al.
Published: (2020-03-01)

A population of CD4hiCD38hi T cells correlates with disease severity in patients with acute malaria
by: Apte, SH, et al.
Published: (2020)

Reduced circulating dendritic cells in acute Plasmodium knowlesi and Plasmodium falciparum malaria despite elevated plasma Flt3 ligand levels
by: Jessica R. Loughland, et al.
Published: (2021-02-01)

Parasite-dependent expansion of TNF receptor II-positive regulatory T cells with enhanced suppressive activity in adults with severe malaria.
by: Gabriela Minigo, et al.
Published: (2009-04-01)

Circulating neutrophil extracellular traps and neutrophil activation are increased in proportion to disease severity in human malaria
by: Kho, S, et al.
Published: (2018)

Preserved dendritic cell HLA-DR expression and reduced regulatory T cell activation in asymptomatic Plasmodium falciparum and P. vivax infection.
by: Kho, S, et al.
Published: (2015)

The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density
by: Slater, HC, et al.
Published: (2019)

Characterization of blood dendritic and regulatory T cells in asymptomatic adults with sub-microscopic Plasmodium falciparum or Plasmodium vivax infection.
by: Kho, S, et al.
Published: (2016)

Increased circulating myeloid-derived suppressor cells in vivax malaria and severe falciparum malaria
by: Leonardo, L, et al.
Published: (2022)

Platelets kill circulating parasites of all major Plasmodium species in human malaria
by: Kho, S, et al.
Published: (2018)

Differential cellular recognition of antigens during acute Plasmodium falciparum and Plasmodium vivax malaria.
by: Salwati, E, et al.
Published: (2011)

Author Correction: The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density
by: Hannah C. Slater, et al.
Published: (2019-06-01)

Antibodies to Plasmodium falciparum and Plasmodium vivax merozoite surface protein 5 in Indonesia: species-specific and cross-reactive responses.
by: Woodberry, T, et al.
Published: (2008)

Single cell transcriptomics shows that malaria promotes unique regulatory responses across multiple immune cell subsets
by: Nicholas L. Dooley, et al.
Published: (2023-11-01)

Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children
by: Oyong, DA, et al.
Published: (2021)

Loss of complement regulatory proteins on red blood cells in mild malarial anaemia and in Plasmodium falciparum induced blood-stage infection
by: Damian A. Oyong, et al.
Published: (2019-09-01)

Human T cell recognition of the blood stage antigen Plasmodium hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malaria.
by: Woodberry, T, et al.
Published: (2009)

The question of the early diagnosis of asymptomatic and subpatent malaria in pregnancy: Implications for diagnostic tools in a malaria endemic area
by: G.N. Uyaiabasi, et al.
Published: (2023-09-01)

Loss of complement regulatory proteins on uninfected erythrocytes in vivax and falciparum malaria anemia
by: Oyong, DA, et al.
Published: (2018)

Acute malaria induced antibodies against merozoite surface protein 5: frequent induction and analysis of cross-reactivity between P-falciparum and P-vivax.
by: Woodberry, T, et al.
Published: (2008)

Subpatent Plasmodium with mutant pfmdr1, pfcrt, and pvmdr1 alleles from endemic provinces in Mindanao, the Philippines: implications for local malaria elimination
by: Mary Grace B. Dacuma, et al.
Published: (2021-09-01)

Human T cell recognition of the blood stage antigen <it>Plasmodium </it>hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malaria
by: Woodberry Tonia, et al.
Published: (2009-06-01)

Malaria-related hospitalization during childhood in Papua, Indonesia: A retrospective cohort study
by: Douglas, NM, et al.
Published: (2020)

Primaquine-induced severe hemolysis in the absence of concomitant malaria: effects on G6PD activity and renal function
by: Douglas, NM, et al.
Published: (2022)

IgM in human immunity to Plasmodium falciparum malaria
by: Boyle, MJ, et al.
Published: (2019)

Treatment-seeking behavior after the implementation of a unified policy of dihydroartemisinin-piperaquine for the treatment of uncomplicated malaria in Papua, Indonesia
by: Devine, A, et al.
Published: (2017)

The risk of adverse clinical outcomes following treatment of Plasmodium vivax malaria with and without primaquine in Papua, Indonesia
by: Thriemer, K, et al.
Published: (2020)

Flow cytofluorimetric detection and immunophenotyping of platelet-monocyte complexes in peripheral blood
by: O. V. Pavlov, et al.
Published: (2021-05-01)

Clustering of subpatent infections in households with asymptomatic rapid diagnostic test-positive cases in Bioko Island, Equatorial Guinea independent of travel to regions of higher malaria endemicity: a cross-sectional study
by: Dianna E. B. Hergott, et al.
Published: (2021-07-01)

The immunophenotype of osteoclasts and macrophage polykaryons
by: Maggiani, F, et al.
Published: (2011)

The immunophenotype of osteoclasts and macrophage polykaryons.
by: Maggiani, F, et al.
Published: (2011)

Immunophenotyping beyond the limits of time
by: J. Fréderique de Graaf, et al.
Published: (2023-10-01)

Immunophenotypic characteristics of brain metastases
by: G. A. Demyashkin, et al.
Published: (2018-12-01)

Immunophenotyping of pulmonary sarcomatoid carcinoma
by: Yu Ma, et al.
Published: (2022-10-01)

Radiomic Immunophenotyping of GSEA-Assessed Immunophenotypes of Glioblastoma and Its Implications for Prognosis: A Feasibility Study
by: Justin Bo-Kai Hsu, et al.
Published: (2020-10-01)

Differential immunophenotype of circulating monocytes from pregnant women in response to viral ligands
by: Marcelo Farias-Jofre, et al.
Published: (2023-05-01)

Age-related susceptibility to severe malaria associated with galectin-2 in highland Papuans.
by: Randall, L, et al.
Published: (2010)