Trapping or slowing the diffusion of T cell receptors at close contacts initiates T cell signaling
T cell activation is initiated by T cell receptor (TCR) phosphorylation. This requires the local depletion of large receptor-type phosphatases from “close contacts” formed when T cells interact with surfaces presenting agonistic TCR ligands, but exactly how the ligands potentiate signaling is unclea...
| Auteurs principaux: | , , , , , , , , , , |
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| Format: | Journal article |
| Langue: | English |
| Publié: |
National Academy of Sciences
2021
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