The use of iPSC-derived neurons to investigate the role of clusterin trafficking in Alzheimer’s disease
<p>Clusterin’s role in neurodegeneration and Alzheimer’s disease (AD) remains unclear. Clusterin (CLU) protein expression and trafficking are altered in response to stress; the treatment of rodent neurons with beta-amyloid (Aβ) increases intracellular retention and reduces secretion of cluster...
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| Format: | Thesis |
| Language: | English |
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2021
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