Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces

Epigenetics is of rapidly growing field in drug discovery. Of particular interest is the role of post‐translational modifications to histone and the proteins that read, write, and erase such modifications. The development of inhibitors for reader domains has focused on single domains. One of the maj...

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Bibliographic Details
Main Authors: Brennan, P, Bowkett, D, Talon, R, Tallant, C, Schofield, C, Bruton, G, Von Delft, F, Knapp, S
Format: Journal article
Published: Wiley‐VCH Verlag 2018