The clinical diagnosis and treatment of phospholipase C zeta (PLCζ) deficiency and the development of a nanoparticle-mediated delivery method for sperm
<strong>Background:</strong> Sperm-specific phospholipase C zeta (PLCζ) triggers Ca2+ oscillations that activate oocytes in mammals. The regulatory mechanisms of PLCζ expression remain unknown. Sperm from patients with PLCζ deficiency or functional mutagenesis in the PLCZ1 gene are unabl...
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| Format: | Thesis |
| Language: | English |
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2024
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