Investigating the pathogenesis of congenital insensitivity to pain using gene-editing in an in vitro model

<p>The voltage gated sodium channel Nav1.7 is a key component of the mammalian nociceptive system. Homozygous loss of function mutations in SCN9A, the gene that encodes Nav1.7, cause congenital insensitivity to pain (CIP) in humans. Affected individuals are unable to perceive pain in respon...