Structural insights into corepressor recognition by antagonist-bound estrogen receptors.

Direct recruitment of transcriptional corepressors to estrogen receptors (ER) is thought to contribute to the tissue-specific effects of clinically important ER antagonists. Here, we present the crystal structures of two affinity-selected peptides in complex with antagonist-bound ERalpha ligand-bind...

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Những tác giả chính: Heldring, N, Pawson, T, McDonnell, D, Treuter, E, Gustafsson, J, Pike, A
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2007