Stochasticity in the genotype-phenotype map: Implications for the robustness and persistence of bet-hedging
Non–genetic variation in phenotypes, or bet–hedging, has been observed as a driver of drug resistance in both bacterial infections and cancers. Here, we study how bet–hedging emerges in the genotype–phenotype mapping through a simple mechanistic model: a molecular switch. By using model Chemical Rea...
| Main Authors: | , , , |
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| Format: | Journal article |
| Published: |
Genetics Society of America
2016
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