Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion

Malignant pleural effusion (MPE) is a frequent metastatic manifestation of human cancers. While we previously identified KRAS mutations as molecular culprits of MPE formation, the underlying mechanism remained unknown. Here, we determine that non-canonical IKKα-RelB pathway activation of KRAS-mutant...

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Bibliographic Details
Main Authors:	Marazioti, A, Lilis, I, Vreka, M, Apostolopoulou, H, Kalogeropoulou, A, Giopanou, I, Giotopoulou, G, Krontira, A, Iliopoulou, M, Kanellakis, N, Agalioti, T, Giannou, A, Jones-Paris, C, Iwakura, Y, Kardamakis, D, Blackwell, T, Taraviras, S, Spella, M, Stathopoulos, G
Format:	Journal article
Published:	Nature Publishing Group 2018

Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion

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