Oxetane cis- and trans-beta-amino-acid scaffolds from L-rhamnose by efficient S(N)2 reactions in oxetane rings; pseudoenantiomeric analogues of the antibiotic oxetin
An efficient multigram ring contraction of a 1,4-lactone 2-O-triflate derived from l-rhamnose - with retention of configuration in the ring closure - is the key step in the preparation of a series of oxetanes, which are pseudoenantiomeric analogues of the naturally occurring antibiotic oxetin, an ox...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2004
|