A model invalidation-based approach for elucidating biological signalling pathways, applied to the chemotaxis pathway inR. sphaeroides

Background Developing methods for understanding the connectivity of signalling pathways is a major challenge in biological research. For this purpose, mathematical models are routinely developed based on experimental observations, which also allow the prediction of the system behaviour under differ...

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Bibliographic Details
Main Authors: Roberts, M, August, E, Hamadeh, A, Maini, P, McSharry, P, Armitage, J, Papachristodoulou, A
Format: Journal article
Published: Biomedical Central 2009