Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.

Metabolic reprogramming is a hallmark of cancer cells. Strap (stress-responsive activator of p300) is a novel TPR motif OB-fold protein that contributes to p53 transcriptional activation. We show here that, in addition to its established transcriptional role, Strap is localised at mitochondria where...

ver descrição completa

Detalhes bibliográficos
Main Authors: Maniam, S, Coutts, A, Stratford, MR, McGouran, J, Kessler, B, La Thangue, N
Formato: Journal article
Idioma:English
Publicado em: Nature Publishing Group 2015