Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting.

Malaria has been a major selective force on the human population, and several erythrocyte polymorphisms have evolved that confer resistance to severe malaria. Plasmodium falciparum rosetting, a parasite virulence phenotype associated with severe malaria, is reduced in blood group O erythrocytes comp...

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Detalhes bibliográficos
Principais autores: Rowe, J, Handel, I, Thera, M, Deans, A, Lyke, K, Koné, A, Diallo, D, Raza, A, Kai, O, Marsh, K, Plowe, C, Doumbo, O, Moulds, J
Formato: Journal article
Idioma:English
Publicado em: 2007