Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.

Structural basis for Par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4.

The mammalian SPRY domain- and SOCS box-containing proteins, SPSB1 to SPSB4, belong to the SOCS box family of E3 ubiquitin ligases. Substrate recognition sites for the SPRY domain are identified only for human Par-4 (ELNNNL) and for the Drosophila orthologue GUSTAVUS binding to the DEAD-box RNA heli...

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Bibliographic Details
Main Authors: Filippakopoulos, P, Low, A, Sharpe, T, Uppenberg, J, Yao, S, Kuang, Z, Savitsky, P, Lewis, R, Nicholson, SE, Norton, R, Bullock, A
Format: Journal article
Language:English
Published: 2010

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