Assessment of the functional impact of amino acid variants in DNA damage response proteins using orthologue complementation
The DNA in every cell of the human body is subject to a barrage of exogenous and endogenous mutagens, causing tens of thousands of DNA lesions per cell, per day. To counteract this assault, cells have evolved a network of proteins that work to detect and repair the DNA lesions, collectively known a...
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| Format: | Thesis |
| Language: | English |
| Published: |
2023
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