Secrets of a covalent interaction for biomaterials and biotechnology: SpyTag and SpyCatcher

SpyTag is a short peptide that forms an isopeptide bond upon encountering its protein partner SpyCatcher. This covalent peptide interaction is a simple and powerful tool for bioconjugation and extending what protein architectures are accessible. Here we review the origin and mechanism of SpyTag/SpyC...

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Bibliographic Details
Main Authors: Reddington, S, Howarth, M
Format: Journal article
Published: Elsevier 2015