Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry

Class I phosphoinositide-3-kinase (PI3K) isoforms generate the intracellular signaling lipid, phosphatidylinositol(3,4,5)trisphosphate (PtdIns(3,4,5)P 3). PtdIns(3,4,5)P 3 regulates major aspects of cellular behavior, and the use of both genetic and pharmacological intervention has revealed importan...

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Bibliographic Details
Main Authors: Clark, J, Anderson, K, Juvin, V, Smith, T, Karpe, F, Wakelam, M, Stephens, L, Hawkins, P
Format: Journal article
Language:English
Published: 2011