Biological relevance of DNA polymerase beta and translesion synthesis polymerases to cancer and its treatment

Biological relevance of DNA polymerase beta and translesion synthesis polymerases to cancer and its treatment

The cellular genome is constantly subject to DNA damage caused by endogenous factors or exogenously by damaging agents such as ionizing radiation or various anticancer agents. The base excision repair (BER) enzyme, DNA polymerase β, and the polymerases involved in translesion synthesis (TLS) have be...

Podrobná bibliografie
Hlavní autoři:	Nicolay, N, Helleday, T, Sharma, R
Médium:	Journal article
Jazyk:	English
Vydáno:	2012

Podobné jednotky

Biological relevance of DNA polymerase β and translesion synthesis polymerases to cancer and its treatment.
Autor: Nicolay, N, a další
Vydáno: (2012)

Regulation of translesion synthesis DNA polymerase eta by monoubiquitination.
Autor: Bienko, M, a další
Vydáno: (2010)

Translesion synthesis: Y-family polymerases and the polymerase switch.
Autor: Lehmann, A, a další
Vydáno: (2007)

Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer.
Autor: Parsons, J, a další
Vydáno: (2013)

Translesion synthesis and error-prone polymerases.
Autor: Green, C, a další
Vydáno: (2005)

Translesion Synthesis Polymerases in the Prevention and Promotion of Carcinogenesis
Autor: L. Jay Stallons, a další
Vydáno: (2010-01-01)

Role of Translesion Synthesis DNA Polymerases in DNA Replication in the Presence of a Weak DNA Polymerase δ in Saccharomyces cerevisiae
Autor: Likui Zhang, a další
Vydáno: (2018-02-01)

Architecture of Y-Family DNA Polymerases Relevant to Translesion DNA Synthesis as Revealed in Structural and Molecular Modeling Studies
Autor: Sushil Chandani, a další
Vydáno: (2010-01-01)

SCREENING OF ONCOGENIC VARIANTS IN DNA POLYMERASES WITH TRANSLESION SYNTHESIS ACTIVITY IN MYELODYSPLASTIC NEOPLASM
Autor: RTG Oliveira, a další
Vydáno: (2023-10-01)

Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery
Autor: Peter Tonzi, a další
Vydáno: (2018-11-01)

A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.
Autor: Kinrin Yamanaka, a další
Vydáno: (2012-01-01)

Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1
Autor: Tyler M. Weaver, a další
Vydáno: (2022-05-01)

Division of labor of Y-family polymerases in translesion-DNA synthesis for distinct types of DNA damage.
Autor: Yuriko Inomata, a další
Vydáno: (2021-01-01)

Polymerase exchange on single DNA molecules reveals processivity clamp control of translesion synthesis
Autor: Kath, James E., a další
Vydáno: (2014)

Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication
Autor: Soriano, I, a další
Vydáno: (2021)

Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.
Autor: Bienko, M, a další
Vydáno: (2005)

Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication.
Autor: Ignacio Soriano, a další
Vydáno: (2021-07-01)

Cryo-EM structure of translesion DNA synthesis polymerase ζ with a base pair mismatch
Autor: Radhika Malik, a další
Vydáno: (2022-02-01)

A Genetic Selection for dinB Mutants Reveals an Interaction between DNA Polymerase IV and the Replicative Polymerase That Is Required for Translesion Synthesis.
Autor: Michelle K Scotland, a další
Vydáno: (2015-09-01)

Human DNA polymerases lambda and beta show different efficiencies of translesion DNA synthesis past abasic sites and alternative mechanisms for frameshift generation.
Autor: Blanca, G, a další
Vydáno: (2004)

Proteasomal regulation of the mutagenic translesion DNA polymerase, Saccharomyces cerevisiae Rev1
Autor: Wiltrout, Mary Ellen, a další
Vydáno: (2015)

Biochemistry: Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis
Autor: Bienko, M, a další
Vydáno: (2005)

Effect of a Monofunctional Phenanthriplatin-DNA Adduct on RNA Polymerase II Transcriptional Fidelity and Translesion Synthesis
Autor: Kellinger, Matthew W., a další
Vydáno: (2014)

Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis.
Autor: Maga, G, a další
Vydáno: (2002)

Translesion synthesis polymerases are dispensable for C. elegans reproduction but suppress genome scarring by polymerase theta-mediated end joining.
Autor: Ivo van Bostelen, a další
Vydáno: (2020-04-01)

Contributions of replicative and translesion DNA polymerases to mutagenic bypass of canonical and atypical UV photoproducts
Autor: Brittany N. Vandenberg, a další
Vydáno: (2023-05-01)

Structural insight into recruitment of translesion DNA polymerase Dpo4 to sliding clamp PCNA.
Autor: Xing, G, a další
Vydáno: (2009)

The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ.
Autor: Carine Tellier-Lebegue, a další
Vydáno: (2017-12-01)

SOS genes are rapidly induced while translesion synthesis polymerase activity is temporally regulated
Autor: Olaug Elisabeth Torheim Bergum, a další
Vydáno: (2024-03-01)

A Well-Conserved Archaeal B-Family Polymerase Functions as an Extender in Translesion Synthesis
Autor: Xu Feng, a další
Vydáno: (2022-02-01)

Analysis of translesion polymerases in colorectal cancer cells following cetuximab treatment: A network perspective
Autor: Anubrata Das, a další
Vydáno: (2024-01-01)

Correction: The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ.
Autor: Carine Tellier-Lebegue, a další
Vydáno: (2018-02-01)

Single-molecule imaging reveals multiple pathways for the recruitment of translesion polymerases after DNA damage
Autor: Elizabeth S. Thrall, a další
Vydáno: (2017-12-01)

Expression of DNA translesion synthesis polymerase η in head and neck squamous cell cancer predicts resistance to gemcitabine and cisplatin-based chemotherapy.
Autor: Wendi Zhou, a další
Vydáno: (2013-01-01)

Intramolecular telomeric G-quadruplexes dramatically inhibit DNA synthesis by replicative and translesion polymerases, revealing their potential to lead to genetic change.
Autor: Deanna N Edwards, a další
Vydáno: (2014-01-01)

The SOS Error-Prone DNA Polymerase V Mutasome and β-Sliding Clamp Acting in Concert on Undamaged DNA and during Translesion Synthesis
Autor: Adhirath Sikand, a další
Vydáno: (2021-05-01)

Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres
Autor: Laura Garcia-Exposito, a další
Vydáno: (2016-11-01)

Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta.
Autor: Nicolay, N, a další
Vydáno: (2012)

Competition between replicative and translesion polymerases during homologous recombination repair in Drosophila.
Autor: Daniel P Kane, a další
Vydáno: (2012-01-01)

Translesion DNA synthesis in the context of cancer research
Autor: Knobel Philip A, a další
Vydáno: (2011-11-01)