Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic
Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for cl...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
BioMed Central
2017
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| _version_ | 1797085392786161664 |
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| author | Nicol, D Eckstein, L Morrison, M Sherkow, J Otlowski, M Whitton, T Bubela, T Burdon, K Chalmers, D Chan, S Charlesworth, J Critchley, C Crossley, M de Lacey, S Dickinson, J Hewitt, A Kamens, J Kato, K Kleiderman, E Kodama, S Liddicoat, J Mackey, D Newson, A Nielsen, J Wagner, J McWhirter, R |
| author_facet | Nicol, D Eckstein, L Morrison, M Sherkow, J Otlowski, M Whitton, T Bubela, T Burdon, K Chalmers, D Chan, S Charlesworth, J Critchley, C Crossley, M de Lacey, S Dickinson, J Hewitt, A Kamens, J Kato, K Kleiderman, E Kodama, S Liddicoat, J Mackey, D Newson, A Nielsen, J Wagner, J McWhirter, R |
| author_sort | Nicol, D |
| collection | OXFORD |
| description | Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of CRISPR-mediated somatic cell therapy. |
| first_indexed | 2024-03-07T02:08:21Z |
| format | Journal article |
| id | oxford-uuid:9fc20fe2-3c18-4260-87ac-d1656af2850a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T02:08:21Z |
| publishDate | 2017 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:9fc20fe2-3c18-4260-87ac-d1656af2850a2022-03-27T02:00:19ZKey challenges in bringing CRISPR-mediated somatic cell therapy into the clinicJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:9fc20fe2-3c18-4260-87ac-d1656af2850aEnglishSymplectic Elements at OxfordBioMed Central2017Nicol, DEckstein, LMorrison, MSherkow, JOtlowski, MWhitton, TBubela, TBurdon, KChalmers, DChan, SCharlesworth, JCritchley, CCrossley, Mde Lacey, SDickinson, JHewitt, AKamens, JKato, KKleiderman, EKodama, SLiddicoat, JMackey, DNewson, ANielsen, JWagner, JMcWhirter, RGenome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of CRISPR-mediated somatic cell therapy. |
| spellingShingle | Nicol, D Eckstein, L Morrison, M Sherkow, J Otlowski, M Whitton, T Bubela, T Burdon, K Chalmers, D Chan, S Charlesworth, J Critchley, C Crossley, M de Lacey, S Dickinson, J Hewitt, A Kamens, J Kato, K Kleiderman, E Kodama, S Liddicoat, J Mackey, D Newson, A Nielsen, J Wagner, J McWhirter, R Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic |
| title | Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic |
| title_full | Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic |
| title_fullStr | Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic |
| title_full_unstemmed | Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic |
| title_short | Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic |
| title_sort | key challenges in bringing crispr mediated somatic cell therapy into the clinic |
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