IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo.

We present evidence that donor-reactive CD4(+) T cells present in mice tolerant to donor alloantigens are phenotypically and functionally heterogeneous. CD4(+) T cells contained within the CD45RB(high) fraction remained capable of mediating graft rejection when transferred to donor alloantigen-graft...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors: Hara, M, Kingsley, C, Niimi, M, Read, S, Turvey, SE, Bushell, A, Morris, P, Powrie, F, Wood, K
Format: Journal article
Sprog:English
Udgivet: 2001