COGENT: evaluating the consistency of gene co-expression networks

Gene co-expression networks can be constructed in multiple different ways, both in the use of different measures of co-expression, and in the thresholds applied to the calculated co-expression values, from any given dataset. It is often not clear which co-expression network construction method shoul...

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Dettagli Bibliografici
Autori principali: Bozhilova, LV, Pardo-Diaz, J, Reinert, G, Deane, CM
Natura: Journal article
Lingua:English
Pubblicazione: Oxford University Press 2020
Descrizione
Riassunto:Gene co-expression networks can be constructed in multiple different ways, both in the use of different measures of co-expression, and in the thresholds applied to the calculated co-expression values, from any given dataset. It is often not clear which co-expression network construction method should be preferred. COGENT provides a set of tools designed to aid the choice of network construction method without the need for any external validation data.