Perfect adaptation of CD8+ T cell responses to constant antigen input over a wide range of affinity is overcome by costimulation
Maintaining and limiting T cell responses to constant antigen stimulation is critical to eliminate pathogens and maintain self-tolerance, respectively. Antigen recognition by the T cell receptor (TCR) induces signalling that can activate T cells to produce cytokines and downregulation of the TCR. Pr...
| Main Authors: | , , , , |
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| Format: | Working paper |
| Published: |
2019
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