Discovery of a highly selective cell‐active inhibitor of the histone lysine demethylases KDM2/7

Discovery of a highly selective cell‐active inhibitor of the histone lysine demethylases KDM2/7

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Histone lysine demethylases (KDMs) are of critical importance in the epigenetic regulation of gene expression, yet there are few selective, cell-permeable inhibitors or suitable tool compounds for these enzymes. Here we describe the discovery of a new class of inhibitor that is highly selective towa...

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Bibliographic Details
Main Authors: Gerken, P, Wolstenhume, J, Tumbler, A, Hatch, S, Zhang, Y, Muller, S, Chandler, S, Mair, B, Li, F, Nijman, S, Konietzny, R, Szommer, T, Yapp, C, Fedorov, O, Benesch, J, Vedadi, M, Kessler, B, Kawamura, A, Brennan, P, Smith, M
Format: Journal article
Published: Wiley 2017

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