Three-dimensional scaffolds: An in vitro strategy for the biomimetic modelling of in vivo tumour biology

Three-dimensional scaffolds: An in vitro strategy for the biomimetic modelling of in vivo tumour biology

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Limitations associated with the study of cancer biology in vitro, including a lack of extracellular matrix, have prompted an interest in analysing the behaviour of tumour cells in a three-dimensional environment. Such model systems can be used to better understand malignancy and metastasis and a can...

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Detalhes bibliográficos
Principais autores: Sharma, A, Sharma, N, Lavy, C, Kiltie, A, Hamdy, F, Czernuszka, J
Formato: Journal article
Idioma:English
Publicado em: Kluwer Academic Publishers 2014
Descrição
Resumo:Limitations associated with the study of cancer biology in vitro, including a lack of extracellular matrix, have prompted an interest in analysing the behaviour of tumour cells in a three-dimensional environment. Such model systems can be used to better understand malignancy and metastasis and a cancer's response to therapies. We review the materials that have been used in such models to date, including their fabrication techniques and the results from their study in cancer. Despite the variety of materials available, obstacles remain to perfecting an in vitro model system and we outline some of the challenges yet to be overcome. © 2014 Springer Science+Business Media New York.

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