Modulating microtubule stability enhances the cytotoxic response of cancer cells to Paclitaxel.
The extracellular matrix protein TGFBI enhances the cytotoxic response of cancer cells to paclitaxel by affecting integrin signals that stabilize microtubules. Extending the implications of this knowledge, we tested the more general hypothesis that cancer cell signals which increase microtubule stab...
Main Authors: | Ahmed, A, Wang, X, Lu, Z, Goldsmith, J, Le, X, Grandjean, G, Bartholomeusz, G, Broom, B, Bast, R |
---|---|
Format: | Journal article |
Language: | English |
Published: |
2011
|
Similar Items
-
Paclitaxel sensitivity of ovarian cancer can be enhanced by knocking down pairs of kinases that regulate MAP4 phosphorylation and microtubule stability
by: Yang, H, et al.
Published: (2018) -
Bisphosphorylated PEA-15 sensitizes ovarian cancer cells to paclitaxel by impairing the microtubule-destabilizing effect of SCLIP.
by: Xie, X, et al.
Published: (2013) -
The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells.
by: Le, X, et al.
Published: (2011) -
The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel.
by: Ahmed, A, et al.
Published: (2007) -
A genistein derivative, ITB-301, induces microtubule depolymerization and mitotic arrest in multidrug-resistant ovarian cancer.
by: Ahmed, A, et al.
Published: (2011)