The nicotinic acetylcholine receptor: from molecular model to single-channel conductance.

The nicotinic acetylcholine receptor (nAChR) is the archetypal ligand-gated ion channel. A model of the alpha7 homopentameric nAChR is described in which the pore-lining M2 helix bundle is treated atomistically and the remainder of the molecule is treated as a "low resolution" cylinder. Th...

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Hlavní autoři: Adcock, C, Smith, G, Sansom, MS
Médium: Journal article
Jazyk:English
Vydáno: 2000

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